| CAS NO: | 208107-14-6 |
| 生物活性 | Temozolomide-d3 (NSC 362856-d3) is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral activeDNA alkylatingagent that crosses the blood-brain barrier. Temozolomide is also aproautophagicandproapoptoticagent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2]. | |||||||||
| 体外研究 (In Vitro) | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. | |||||||||
| 分子量 | 197.17 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C6H3D3N6O2 | |||||||||
| CAS 号 | 208107-14-6 | |||||||||
| 中文名称 | 替莫唑胺 d3 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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