LP-184

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LP-184

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

924835-67-6

LP-184 (compound 6)，一种酰基氟乙烯类似物，能够抑制肿瘤生长。LP-184 在卵巢、结肠、前列腺和胰腺细胞系中具有有效的抗癌活性，来自专利 WO2007019308A2。

生物活性

LP-184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP-184 has potent anti-cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2).

IC₅₀& Target

IC50: 0.68 μM (HT29); 0.6 μM (OVCAR-3); 16 μM (AsPC-1); 0.14 μM (PC-3)

体外研究
(In Vitro)

LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI₅₀s of 0.68, 0.6, 16 and 0.14 μM, respectively^[1].
LP-184 displays IC₅₀s of 800nM and 210 nM for anti-cancer activitie in the thymidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay^[1].

体内研究
(In Vivo)

LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively^[1].

Animal Model:	Mice (MV522 tumors)^[1]
Dosage:	7.5 and 10 mg/kg
Administration:	I.p; 21day
Result:	Effective agent for human anti-tumor therapy.

分子量

304.34

Formula

C₁₆H₂₀N₂O₄

CAS 号

924835-67-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.