Elliptinium acetate

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Elliptinium acetate

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CAS NO:

58337-35-2

NSC 264137
Celiptium

Elliptinium acetate (NSC 264137) 是一种 DNA 插层剂，对 L1 210 细胞具有较强的细胞毒性，并且能与 L1210 细胞的核酸共价结合。Elliptinium acetate 可用于癌症，尤其是转移性乳腺癌的研究。

生物活性

Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used incancerresearch, particularly in metastatic breastcancer^[1]^[2].

IC₅₀& Target

Nucleic acids^[1]^[2].

体外研究
(In Vitro)

Elliptinium (0.35 μM; 1 h) (9-OH-NME3) shows highly stable covalent bonding to nucleic acids of L1210 cells^[1].

Cell Viability Assay^[1]

Cell Line:	L1 210 cells
Concentration:	0.35 μM
Incubation Time:	1 h
Result:	Exhibited highly stable covalent bonding to DNA and RNA. Showed no reversal of binding as cells went on replicating during a 40-h period.

分子量

336.38

Formula

C₂₀H₂₀N₂O₃

CAS 号

58337-35-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.