Triciferol

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Triciferol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

957214-00-5

Triciferol 是一种具有VDR激动剂和HDAC拮抗剂联合作用的多配体。Triciferol 直接与 VDR结合 (IC₅₀=87 nM)，在一些 1,25D 靶基因上作为具有 1,25D 样效力的激动剂发挥作用。Triciferol 诱导显著的微管蛋白高乙酰化，并增强组蛋白乙酰化。抗增殖和细胞毒性活性。

生物活性

Triciferol functions as a multiple ligand with combinedVDRagonist andHDACantagonist activities. Triciferol binds directly to the VDR (IC₅₀=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities^[1].

体外研究
(In Vitro)

Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells^[1].
Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D^[1].

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB231 breast cancer cells
Concentration:	0-10000 nM
Incubation Time:	0-72 hours
Result:	Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above.

分子量

429.59

性状

Solid

Formula

C₂₆H₃₉NO₄

CAS 号

957214-00-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(232.78 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3278 mL	11.6390 mL	23.2780 mL
5 mM	0.4656 mL	2.3278 mL	4.6556 mL
10 mM	0.2328 mL	1.1639 mL	2.3278 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light, stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。