Mito-TRFS 是第一个关闭式探针,用于对活细胞中的线粒体硫氧还蛋白还原酶 (TrxR2) 进行成像。
Cas No. | 1859102-62-7 |
别名 | MitoTRFS; Mito TRFS; Mito-TRFS |
Canonical SMILES | O=C(C1=CC=C(NC(OC2CSSC2)=O)C3=CC=CC4=C13)N(CCOCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C4=O.[I-] |
分子式 | C38H34IN2O5PS2 |
分子量 | 820.7 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Mito-TRFS is the first off-on probe for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells. Reference: [1]: Liu Y, Ma H, Zhang L, Cui Y, Liu X, Fang J. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model. Chem Commun (Camb). 2016 Feb 7;52(11):2296-9. doi: 10.1039/c5cc09998f. PubMed PMID: 26725656. |