HDAC-IN-38

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HDAC-IN-38

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2408123-36-2

HDAC-IN-38 (化合物 13) 是一种有效的HDAC抑制剂。HDAC-IN-38对HDAC1、2、3、5、6和8表现出类似的微摩尔抑制活性。HDAC-IN-38 增加脑血流量 (CBF)，减轻认知障碍，改善海马萎缩。HDAC-IN-38 还会增加组蛋白乙酰化水平 (H3K14 或 H4K5)。

生物活性

HDAC-IN-38 (compound 13) is a potentHDACinhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity towardHDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5)^[1].

IC₅₀& Target

HDAC8

0.533 μM (IC₅₀)

HDAC6

1.27 μM (IC₅₀)

HDAC3

2.86 μM (IC₅₀)

HDAC1

3.82 μM (IC₅₀)

HDAC5

6.27 μM (IC₅₀)

HDAC2

6.62 μM (IC₅₀)

分子量

461.98

Formula

C₂₇H₂₈ClN₃O₂

CAS 号

2408123-36-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.