PARP-1/HDAC-IN-1

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PARP-1/HDAC-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

PARP-1/HDAC-IN-1 是一种PARP-1/HDAC6双重靶向抑制剂，IC₅₀值分别为 68.90 nM 和 510 nM。PARP-1/HDAC-IN-1 显示出显着的抗癌、抗迁移和抗血管生成活性。

生物活性

PARP-1/HDAC-IN-1 is aPARP-1/HDAC6dual targeting inhibitor withIC₅₀s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities^[1].

IC₅₀& Target^[1]

PARP-1

68.90 nM (IC₅₀)

HDAC6

510 nM (IC₅₀)

HDAC2

42130 nM (IC₅₀)

HDAC3

7220 nM (IC₅₀)

体外研究
(In Vitro)

PARP-1/HDAC-IN-1 (Compound 1–8-6) possesses potent inhibitory activity against MDA-MB-436, ES-2, DU145, A549, HCC1937, and Capan-1 cells with IC₅₀values of 0.35 μM, 1.16 μM, 3.38 μM, 5.67 μM, 2.85 μM, and 4.53 μM, respectively^[1].
PARP-1/HDAC-IN-1 (Compound 1–8-6; 0.3-10 μM) is able to heighten expression level of acetylated α-tubulin with marginal effects to acetylated histones H3 and H4^[1].

分子量

402.40

Formula

C₂₂H₁₈N₄O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.