NMDAR/HDAC-IN-1

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NMDAR/HDAC-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

NMDAR/HDAC-IN-1 (Compound 9d) 是一种NMDAR和HDAC双重抑制剂，对 NMDAR 的K_i值为 0.59 μM，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的IC₅₀分别为 2.67、8.00、2.21、0.18 和 0.62 μM。NMDAR/HDAC-IN-1 能有效穿透血脑屏障。

生物活性

NMDAR/HDAC-IN-1 (Compound 9d) is a dualNMDARandHDACinhibitor with aK_iof 0.59 μM for NMDAR andIC₅₀values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM forHDAC1,HDAC2,HDAC3,HDAC6andHDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier^[1].

IC₅₀& Target

NMDA Receptor

0.59 μM (Ki)

HDAC6

0.18 μM (IC₅₀)

HDAC8

0.62 μM (IC₅₀)

HDAC3

2.21 μM (IC₅₀)

HDAC1

2.67 μM (IC₅₀)

HDAC2

8.00 μM (IC₅₀)

体外研究
(In Vitro)

NMDAR/HDAC-IN-1 (Compound 9d) increases the level of AcTubulin in MV4-11 cells and rescues PC-12 cells from H₂O₂-induced cytotoxicity with EC₅₀of 0.94 μM^[1].

分子量

368.47

Formula

C₂₂H₂₈N₂O₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.