HDAC8/BRPF1-IN-1

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HDAC8/BRPF1-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2484255-85-6

HDAC8/BRPF1-IN-1 (Compound 23a) 是一种HDAC8和BRPF1的双抑制剂，对人 HDAC8 的IC₅₀为 443 nM，对人 BRPF1 的K_d为 67 nM 。 HDAC8/BRPF1-IN-1 对 HDAC1 和 6 的体外活性较低。

生物活性

HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor ofHDAC8andBRPF1with anIC₅₀of 443 nM against humanHDAC8and aK_dof 67 nM against humanBRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity againstHDAC1and 6^[1].

IC₅₀& Target^[1]

hHDAC8

443 nM (IC₅₀)

hBRPF1

67 nM (Ki)

体外研究
(In Vitro)

HDAC8/BRPF1-IN-1 (Compound 23a) (4-100 μM; 24 h) shows antiproliferative activity against acute myeloid leukemia cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	Acute myeloid leukemia cells THP-1 and HL60
Concentration:	4, 20 and 100 μM
Incubation Time:	24 h
Result:	Inhibited THP-1 and HL60 cells growth.

分子量

417.44

Formula

C₁₉H₁₉N₃O₆S

CAS 号

2484255-85-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.