HDAC-IN-49

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HDAC-IN-49

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

HDAC-IN-49 是一种有效的非选择性HDAC(HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC4 和 HDAC6 的IC₅₀分别为 13 nM、14 nM、21 nM、1880 nM 和 10 nM 。HDAC-IN-49 表现出显着的抗白血病活性，但对健康细胞具有低细胞毒性。

生物活性

HDAC-IN-49 is a potent unselectiveHDAC(HDAC) inhibitor withIC₅₀s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM forHDAC1,HDAC2,HDAC3,HDAC4, andHDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells^[1].

IC₅₀& Target^[1]

HDAC1

13 nM (IC₅₀)

HDAC2

14 nM (IC₅₀)

HDAC3

21 nM (IC₅₀)

HDAC4

1880 nM (IC₅₀)

HDAC6

10 nM (IC₅₀)

体外研究
(In Vitro)

HDAC-IN-49 (compound 10h) shows remarkable cytotoxic potential against different therapy-resistant leukemia cell lines, with IC₅₀values of 0.375 μM, 0.218 μM, and 0.285 μM for HAL01, HL60 and Jurkat cells, respectively. HDAC-IN-49 (compound 10h; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells^[1].
HDAC-IN-49 (compound 10h; 6-36 μM; 24 h) shows a dose-dependent increase in the level of acetylation of α-tubulin and histone 3 (H3) in HL60 cells^[1].

Apoptosis Analysis^[1]

Cell Line:	HL60 cells
Concentration:	1 μM and 5 μM
Incubation Time:	48 h
Result:	Resulted in a significant apoptosis induction.

Western Blot Analysis^[1]

Cell Line:	HL60 cells
Concentration:	6 μM, 12 μM, 24 μM, 36 μM
Incubation Time:	24 h
Result:	Increased in the level of acetylation of α-tubulin and histone 3 (H3).

分子量

478.52

Formula

C₂₆H₂₇FN₄O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.