KH-259

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KH-259

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

KH-259 (compound 1) 是一种有效的、选择性和可透过中枢神经系统的HDAC6抑制剂，其IC₅₀为 0.26 μM。KH-259 通过抑制小鼠脑内 HDAC6 产生抗抑郁作用。KH-259 可用于神经退行性疾病研究。

生物活性

KH-259 (compound 1) is a potent, selective and CNS-penetrantHDAC6inhibitor, with anIC₅₀of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition ofHDAC6in the brain. KH-259 can be used for neurodegenerative diseases research^[1].

IC₅₀& Target

HDAC6

0.26 ± 0.2 μM (IC₅₀)

HDAC1

6.7 ± 0.14 μM (IC₅₀)

HDAC4

12.3 ± 0.4 μM (IC₅₀)

体外研究
(In Vitro)

KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes^[1].

体内研究
(In Vivo)

KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain^[1].

分子量

339.43

Formula

C₂₀H₂₅N₃O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.