HDAC-IN-39

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HDAC-IN-39

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CAS NO:

2414046-33-4

HDAC-IN-39 (化合物 16c) 是一种有效的HDAC抑制剂，其IC₅₀值分别为 1.07 μM (HDAC1)、1.47 μM (HDAC2) 和 2.27 μM (HDAC3)。HDAC-IN-39 对微管聚合也有明显抑制作用。HDAC-IN-39 诱导细胞周期阻滞在 G2/M 期。HDAC-IN-39 对耐药癌细胞显示出良好的抗癌活性。

生物活性

HDAC-IN-39 (compound 16c) is a potentHDACinhibitor, withIC₅₀values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistantcancercells^[1].

IC₅₀& Target

HDAC1

1.07 μM (IC₅₀)

HDAC2

1.47 μM (IC₅₀)

HDAC3

2.27 μM (IC₅₀)

HDAC8

>10 μM (IC₅₀)

分子量

502.58

Formula

C₂₇H₂₆N₄O₄S

CAS 号

2414046-33-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.