AChE/HDAC-IN-1

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AChE/HDAC-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2414053-06-6

COX-2-IN-23 (compound A10) 是一种有效的AChE和HDAC抑制剂，其IC₅₀值分别为 0.12 和 0.23 nM。COX-2-IN-23 具有抗氧化活性和金属螯合特性。COX-2-IN-23 可用于阿尔兹海默病研究。

生物活性

COX-2-IN-23 (compound A10) is a potent bothAChEandHDACinhibitor withIC₅₀values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research^[1].

IC₅₀& Target^[1]

HDAC

0.23 nM (IC₅₀)

体外研究
(In Vitro)

COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC₅₀values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively^[1].
COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%)^[1].
COX-2-IN-23 (compound A10) exhibits Cu²⁺chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity^[1].

分子量

478.97

Formula

C₂₆H₂₇ClN₄O₃

CAS 号

2414053-06-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.