HDAC-IN-46

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HDAC-IN-46

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2562386-85-8

HDAC-IN-46 (compound 12c) 是一种有效的HDAC抑制剂，对 HDAC1 和 HDAC6 的IC₅₀分别为 0.21 μM 和 0.021 μM。HDAC-IN-46 在 MDA-MB-231 细胞中上调 p-p38，下调 Bcl-xL 和 cyclin D1。HDAC-IN-46诱导细胞周期 G2 期阻滞和细胞凋亡 (apoptosis)。HDAC-IN-46 可用于研究三阴性乳腺癌 (TNBC)。

生物活性

HDAC-IN-46 (compound 12c) is a potentHDACinhibitor with anIC₅₀value of 0.21 μM and 0.021 μM forHDAC1andHDAC6, respectively. HDAC-IN-46 upregulates p-p38, and downregulatesBcl-xLand cyclin D1 in MDA-MB-231 cells. HDAC-IN-46 induces significant G2 phase arrest andapoptosis. HDAC-IN-46 can be used for researching triple-negative breastcancer(TNBC)^[1].

IC₅₀& Target^[1]

HDAC1

0.21 μM (IC₅₀)

HDAC6

0.021 μM (IC₅₀)

体外研究
(In Vitro)

HDAC-IN-46 (compound 12c) has antiproliferative activity against MDA-MB-231, A549 and MCF-7 with IC₅₀s of 88.46±10.5 μM, 83.34 ± 15.5 μM and 21.4±3.7 μM, respectively^[1].
HDAC-IN-46 (5, 12.5 and 25 μM; 24 h) causes concentration-dependent upregulation of p-p38 and downregulation of Bcl-xL and cyclin D1 in MDA-MB-231 cells^[1].
HDAC-IN-46 (12.5 and 25 μM; 48 h) induces significant G2 phase arrest and apoptosis^[1].

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	5, 12.5 and 25 μM
Incubation Time:	24 h
Result:	Caused concentration-dependent upregulation of p-p38 and downregulation of Bcl-xL and cyclin D1.

Cell Cycle Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	12.5 and 25 μM
Incubation Time:	48 h
Result:	Induced significant G2 phase arrest and apoptosis.

分子量

438.53

Formula

C₂₂H₃₀N₈O₂

CAS 号

2562386-85-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.