HDAC6-IN-14

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HDAC6-IN-14

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

HDAC6-IN-14 是一种高选择性HDAC6(HDAC) 抑制剂，IC₅₀为 42 nM。HDAC6-IN-14 的选择性是 HDAC1/HDAC2/HDAC3/HDAC4 的 100 倍以上。

生物活性

HDAC6-IN-14 is a highly selectiveHDAC6(HDAC) inhibitor with anIC₅₀of 42 nM. HDAC6-IN-14 displays >100-fold selectivity over HDAC1/HDAC2/HDAC3/HDAC4^[1].

IC₅₀& Target^[1]

HDAC6

42 nM (IC₅₀)

HDAC1

8.01 μM (IC₅₀)

HDAC2

4.48 μM (IC₅₀)

HDAC3

8.35 μM (IC₅₀)

HDAC4

>10 μM (IC₅₀)

体外研究
(In Vitro)

HDAC6-IN-14 (compound 10p; 1-5 μM; 48 h) treatment results in a significant apoptosis induction in HL60 cells^[1].
HDAC6-IN-14 (compound 10p; 6-36 μM; 24 h) treatment induces acetylation of α-tubulin but has no effect on Ac-H3 levels even at concentrations of ≤36 μM in HL60 cells^[1].

Apoptosis Analysis^[1]

Cell Line:	HL60 cells
Concentration:	1 μM and 5 μM
Incubation Time:	48 h
Result:	Resulted in a significant apoptosis induction.

Western Blot Analysis^[1]

Cell Line:	HL60 cells
Concentration:	6 μM, 12 μM, 24 μM, 36 μM
Incubation Time:	24 h
Result:	Induced acetylation of α-tubulin but had no effect on Ac-H3 levels.

分子量

443.51

Formula

C₂₄H₃₀FN₃O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.