PIM-1/HDAC-IN-1

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PIM-1/HDAC-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

PIM-1/HDAC-IN-1 (compound 4d) 是一种PIM-1抑制剂，其IC₅₀为 343.87 nM。PIM-1/HDAC-IN-1 对HDAC 1和HDAC 6具有较强的抑制活性和选择性，IC₅₀值分别为 63.65 和 62.39 nM。PIM-1/HDAC-IN-1 在 MCF-7 细胞系中表现出凋亡诱导潜能。PIM-1/HDAC-IN-1 表现为 pre-G1 凋亡，细胞周期阻滞在 G2/M 期。

生物活性

PIM-1/HDAC-IN-1 (compound 4d) is aPIM-1inhibitor, with anIC₅₀of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity againstHDAC1andHDAC6, withIC₅₀values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibitsapoptosisinducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1apoptosisand cell cycle arrest at G2/M phase^[1].

IC₅₀& Target

HDAC6

62.39 ± 3. nM (IC₅₀)

HDAC1

63.65 ± 3. nM (IC₅₀)

HDAC

65.94 ± 3. nM (IC₅₀)

HDAC2

132.62 nM (IC₅₀)

HDAC4

265.47 nM (IC₅₀)

HDAC3

323.02 nM (IC₅₀)

HDAC8

406.66 nM (IC₅₀)

PIM1

343.87 ± 1 nM (IC₅₀)

体外研究
(In Vitro)

PIM-1/HDAC-IN-1 (compound 4d) displays strong antiproliferative activity against cancer cell lines, with GI50 (growth inhibitory activity) ≤ 3 μM (GI50 range from 0.325 to 2.9 μM)^[1].

分子量

373.40

Formula

C₂₂H₁₉N₃O₃

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.