HD-TAC7

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HD-TAC7

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

HD-TAC7 是一种有效的PROTAC HDAC降解剂，对 HDAC1、HDAC2 和 HDAC3 的IC₅₀分别为 3.6 μM、4.2 μM 和 1.1 μM。HD-TAC7 可降低 RAW 264.7 巨噬细胞 NF-κB p65 表达。HD-TAC7 可用于哮喘和慢性阻塞性肺病（COPD）等炎症性疾病的研究。

生物活性

HD-TAC7 is a potentPROTACHDACdegrader withIC₅₀values of 3.6 μM, 4.2 μM and 1.1 μM forHDAC1,HDAC2andHDAC3, respectively. HD-TAC7 can decreasesNF-κBp65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD)^[1].

IC₅₀& Target^[1]

HDAC1

3.6 μM (IC₅₀)

HDAC2

4.2 μM (IC₅₀)

HDAC3

1.1 μM (IC₅₀)

体外研究
(In Vitro)

HD-TAC7 (10 μM; 24 hours) induces an increase of H3K27 acetylation in RAW 264.7 macrophages^[1].
HD-TAC7 (10 μM; 2-48 hours) induces HDAC3 degradation reaching the maximal effect at 6h and lasted at least 48h^[1].
HD-TAC7 (1 and 10 μM; 24 hours) downregulates NF-κB p65 in LPS-treated RAW 264.7 macrophages^[1].

分子量

657.65

Formula

C₃₃H₃₂FN₇O₇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.