HDAC1/6-IN-1

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HDAC1/6-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2630989-02-3

HDAC1/6-IN-1 (化合物 D7) 是一种有效的GLP、HDAC6和HDAC1的多靶点抑制剂，IC₅₀的值分别为 1.3、13 和 89 nM。HDAC1/6-IN-1 能在蛋白水平上抑制 H3K9 的甲基化和去乙酰化。HDAC1/6-IN-1 可诱导癌细胞凋亡和 G0/G1 细胞周期阻滞，并阻止癌细胞迁移和入侵。

生物活性

HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor ofGLP,HDAC6andHDAC1, withIC₅₀values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 inducescancercellapoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion^[1].

IC₅₀& Target

HDAC6

13 nM (IC₅₀)

HDAC1

89 nM (IC₅₀)

分子量

591.74

Formula

C₃₂H₄₅N₇O₄

CAS 号

2630989-02-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.