HDAC-IN-30

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HDAC-IN-30

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CAS NO:

2756809-34-2

HDAC-IN-30 是一种新颖的多靶点HDAC抑制剂，靶点主要有HDAC1(IC₅₀=13.4 nM)，HDAC2(IC₅₀=28.0 nM)，HDAC3(IC₅₀=9.18 nM)，HDAC6(IC₅₀=42.7 nM)，HDAC8(IC₅₀=131 nM)。HDAC-IN-30 表现出非常强大的抗肿瘤作用。

生物活性

HDAC-IN-30 is a novel multi-targetHDACinhibitor, includingHDAC1(IC₅₀=13.4 nM),HDAC2(IC₅₀=28.0 nM),HDAC3(IC₅₀=9.18 nM),HDAC6(IC₅₀=42.7 nM),HDAC8(IC₅₀=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy^[1].

IC₅₀& Target

HDAC1

13.4 nM (IC₅₀)

HDAC2

28.0 nM (IC₅₀)

HDAC3

9.18 nM (IC₅₀)

HDAC6

42.7 nM (IC₅₀)

HDAC8

131 nM (IC₅₀)

体外研究
(In Vitro)

HDAC-IN-30 (compound 8 h; 0.5, 1, 2 μM; 48 hours) can effectively activate the p53 pathway by promoting the phosphorylation of p53^[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours; HepG2 cells) induces cell cycle arrest at the G2 phase in a concentration-dependent manner^[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours) possesses prominent anticancer activity in HepG2 cells^[1].

Western Blot Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	0.5, 1, 2 μM
Incubation Time:	24 hours
Result:	Could effectively activate the p53 pathway by promoting the phosphorylation of p53

Cell Cycle Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	0, 1, 2.5, 5 μM
Incubation Time:	48 hours
Result:	Cells were arrested at the G2 phase in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:	HepG2 cells
Concentration:	0, 1, 2.5, 5 μM
Incubation Time:	24 hours
Result:	Possessed prominent anticancer activity in HepG2 cells.

体内研究
(In Vivo)

HDAC-IN-30 (12, 24 mg/kg; intraperitoneal injection, every two days for 4 weeks) exhibits potent anticancer activity and no side effects even at high dose (24 mg/kg)^[1].

Animal Model:	HepG2 xenograft mouse model^[1]
Dosage:	12, 24 mg/kg
Administration:	Intraperitoneal injection, every 2 days, 4 weeks
Result:	Exhibited potent anticancer activity

分子量

405.45

Formula

C₂₂H₂₃N₅O₃

CAS 号

2756809-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.