KRIBB11

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KRIBB11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

342639-96-7

KRIBB11 是HSF1的抑制剂，IC₅₀值为 1.2 μM。

生物活性

KRIBB11 is an inhibitor ofHeat shock factor 1 (HSF1), withIC₅₀of 1.2 μM.

IC₅₀& Target

HSF1

1.2 μM (IC₅₀)

体外研究
(In Vitro)

KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter^[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 μM, and an IC₅₀of 20-30 μM^[2].

体内研究
(In Vivo)

KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss^[1].

分子量

284.27

性状

Solid

Formula

C₁₃H₁₂N₆O₂

CAS 号

342639-96-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 27 mg/mL(94.98 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.5178 mL	17.5889 mL	35.1778 mL
5 mM	0.7036 mL	3.5178 mL	7.0356 mL
10 mM	0.3518 mL	1.7589 mL	3.5178 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。