Arimoclomol

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Arimoclomol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

289893-25-0

BRX-220 free base

Arimoclomol (BRX-220 free base) 是一种热休克蛋白 (HSP) 的共诱导剂。Arimoclomol 通过增强 Hsp 表达来保护运动神经元，从而通过泛素-蛋白酶体系统直接影响蛋白质聚集及清除错误折叠和装配的蛋白。

生物活性

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP)^[1]. Arimoclomol protects motor neurons by enhancingHspexpression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system^[2].

IC₅₀& Target^[1]

HSP

体内研究
(In Vivo)

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis^[1].

Animal Model:	Male Wistar rats weighing 240 to 270 g^[1]
Dosage:	20 mg/kg
Administration:	Administered intragastrically, for 5 days
Result:	Had a protective effect against CCK-induced acute pancreatitis.

Clinical Trial

分子量

313.78

Formula

C₁₄H₂₀ClN₃O₃

CAS 号

289893-25-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.