HSP90-IN-13

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HSP90-IN-13

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CAS NO:

2446055-29-2

HSP90-IN-13 (compound 5k) 是一种高效的HSP90广谱性抑制剂，IC₅₀为 25.07 nM。HSP90-IN-13 对 EGFR、VEGFR-2 和 Topoisomerase-2 具有多靶点活性。HSP90-IN-13 将 MCF-7 细胞周期阻滞在 G2/M 期，并通过线粒体介导途径诱导细胞凋亡 (apoptosis)。

生物活性

HSP90-IN-13 (compound 5k) is a highly potentHSP90pan inhibitor with anIC₅₀value of 25.07 nM. HSP90-IN-13 has multi-target activity againstEGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and inducesapoptosisof MCF-7 cells through mitochondrial-mediated pathway^[1].

IC₅₀& Target^[1]

HSP90

25.07 nM (IC₅₀)

Topoisomerase-2

25.85 nM (IC₅₀)

EGFR

38.5 nM (IC₅₀)

VEGFR-2

126.95 nM (IC₅₀)

体外研究
(In Vitro)

HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%^[1].
HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC₅₀s of 4.47 μM, 7.55 μM and 4.04 μM, respectively^[1].
HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC₅₀values of 38.5 nM, 126.95 nM and 25.85 nM, respectively^[1].

分子量

483.54

Formula

C₂₆H₂₁N₅O₃S

CAS 号

2446055-29-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.