GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibitIRE1α kinase activityandRNase activitywithIC₅₀s of 20 and 200 nM, respectively.

IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)^[1]

GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC₅₀s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α can be reduced in a dose-dependent manner by GSK2850163 hydrochloride. Increasing concentrations of GSK2850163 hydrochloride are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163 hydrochloride: Ron (IC₅₀=4.4 μM) and FGFR1 V561M (IC₅₀=17 μM)^[1].

482.87

C₂₄H₃₀Cl₃N₃O

2319838-09-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.