Belumosudil mesylate (KD025 mesylate) is a selective inhibitor ofROCK2withIC₅₀s of 105 nM and 24 μM forROCK2andROCK1, respectively. Anti-fibrotic properties^[1].

Belumosudil (SLx-2119; 40 μM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. The microarray hybridized with aRNA from HMVEC treated with Belumosudil, shows a 5-times higher background than the other arrays^[1].

Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males^[2].

548.61

C₂₇H₂₈N₆O₅S

2109704-99-4

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