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Flufenamic Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flufenamic Acid-d4图片
CAS NO:1185071-99-1

Flufenamic acid-d4 是 Flufenamic acid 氘代物。Flufenamic acid 是一种非甾体类抗炎剂,能够抑制COX的活性,激活AMPK的活性,调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+channel),调节非选择性阳离子通道,激活钾离子通道 (K+channel) 等。Flufenamic acid 与TEAD2 YBD 的中央囊袋结合,抑制 TEAD 功能和 TEAD-YAP 依赖性过程,如细胞迁移和增殖。
生物活性

Flufenamic acid-d4 is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activatesAMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

285.25

Formula

C14H6D4F3NO2

CAS 号

1185071-99-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

 
 
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