SARS-CoV-2 nsp14-IN-1

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CAS NO:

2816165-02-1

SARS-CoV-2 nsp14-IN-1 (Compound 3) 是SARS-CoV-2Nsp14 MTase的典型的双底物抑制剂，其活性IC₅₀值为 0.061 μM。SARS-CoV-2 nsp14-IN-1 (Compound 3) 对人类甲基转移酶具有良好的选择性，可拮抗组蛋白赖氨酸、蛋白精氨酸、DNA 和 RNA 等 10 种人甲基转移酶。

生物活性	SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2Nsp14 MTasewith anIC₅₀value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases^[1].
IC₅₀& Target	IC50：0.061 μM (Nsp14 MTase)^[1]
体外研究 (In Vitro)	SARS-CoV-2 nsp14-IN-1 (Compound 3) displays an excellent selectivity profile for Nsp14 MTase With anIC₅₀value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) shows low passive diffusion rates in PAMPA. SARS-CoV-2 nsp14-IN-1 (Compound 3) does not suffer major metabolic liabilities in human plasma and liver S9 fractions^[1].
分子量	456.48
Formula	C₂₀H₂₀N₆O₅S
CAS 号	2816165-02-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.