INCB059872

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INCB059872

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1802909-49-4

INCB059872是一种有效、具有口服活性，选择性和不可逆的赖氨酸特异性去甲基化酶1 (LSD1) 抑制剂。INCB059872可用于髓系白血病的研究。

生物活性

INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor. INCB059872 can be used for the research of myeloid leukemia^[1].

IC₅₀& Target

KDM1/LSD1

体外研究
(In Vitro)

INCB059872 (25 nM; 48 hours; 293T cells) increases enhancer activity and gene expression^[1].
INCB059872 (25 nM; 24 hours; THP-1 cells) makes THP-1 show a growth defect within one cell doubling time or approximately 3 days. INCB059872 (THP-1 cells) regulates PRO-seq analysis identifies genes and enhancers^[1].

Western Blot Analysis^[1]

Cell Line:	293T cells
Concentration:	250 nM
Incubation Time:	48 hours
Result:	Increased enhancer activity and gene expression.

体内研究
(In Vivo)

INCB059872 (10 mg/kg; p.o.; 0, 4, or 6 days; C57BL/6J mice) makes single-cell RNA-seq revealing changes in bone marrow progenitor populations^[1].

Animal Model:	Mice^[1]
Dosage:	10 mg/kg
Administration:	P.o.; 0, 4, or 6 days
Result:	Single-cell RNA-seq revealed changes in bone marrow progenitor populations.

Clinical Trial

分子量

386.53

Formula

C₂₃H₃₄N₂O₃

CAS 号

1802909-49-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.