BI-9321 is a potent, selective and cellular activenuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domainantagonist with aK_dvalue of 166 nM. BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 specifically disrupts histone interactions of theNSD3-PWWP1 domainwith anIC₅₀of 1.2 μM in U2OS cells^[1].

Kd: 166 nM (NSD3-PWWP1)^[1]

BI-9321 is targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 μM. As a single agent, BI-9321 downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells^[1].

360.43

C₂₂H₂₁FN₄

2387510-86-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.