WS6 (WS6; WS 6) is a novel and potent small molecule modulator of β cell proliferation via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway with important biological activity. WS6 is able to ameliorate diabetes, and induce concomitant increases in β cell proliferation and β cell number in RIP-DTA mouse model of β cell ablation.
理化性质和储存条件
| Molecular Weight (MW) | 568.59 |
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| Formula | C29H31F3N6O3 |
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| CAS No. | 1421227-53-3 |
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| Storage | -20℃ for 3 years in powder form |
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| -80℃ for 2 years in solvent |
| Solubility (In vitro) | DMSO: 100 mg/mL (175.9 mM) |
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| Water:<1 mg/mL |
| Ethanol: 100 mg/mL (175.9 mM) |
| Other info | Chemical Name: 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide
InChi Key: FTODTDQFHDJWIQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)
SMILES Code: O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3 |
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| Synonyms | WS-6; WS 6; WS6; |
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