PROTAC TYK2 degradation agent1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

PROTAC TYK2 degradation agent1 是一种有效的亚型选择性TYK2降解剂。PROTAC TYK2 degradation agent1 具有 TYK2 降解活性，DC₅₀值为 14 nM。PROTAC TYK2 degradation agent1 可用于自身免疫性疾病的研究。

生物活性

PROTACTYK2 degradation agent1 is a potent and subtype-selectiveTYK2degrader.PROTACTYK2 degradation agent1 hasTYK2degradation activity withDC₅₀value of 14 nM.PROTACTYK2 degradation agent1 can be used for the research of autoimmune disease^[1].

IC₅₀& Target

DC50: 14 nM (TYK2)^[1]

体外研究
(In Vitro)

PROTAC TYK2 degradation agent1 (degrader 37) (1 μM; 6 h) 选择性抑制 TYK2 蛋白水平^[1]。
PROTAC TYK2 degradation agent1 具有 TYK2 降解活性，DC₅₀值为 14 nM^[1]。

Western Blot Analysis^[1]

Cell Line:	Jurkat cells
Concentration:	1 μM
Incubation Time:	6 h
Result:	Suppressed TYK2 protein levels and effectively induced the degradation of TYK2 in a dose-dependent manner at a low concentration range, with TYK2 degradation slightly decreasing at high concentrations.

分子量

1056.28

Formula

C₅₅H₆₉N₁₃O₇S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.