Pacritinib hydrochloride

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CAS NO:

1228923-43-0

SB-1518 hydrochloride

Pacritinib hydrochloride 是一种有效的野生型JAK2和JAK2^V617F突变型抑制剂，IC₅₀分别为 23 nM 和 19 nM。Pacritinib hydrochloride 也抑制FLT3及其突变型FLT3^D835Y，IC₅₀分别为 22 nM 和 6 nM。Pacritinib hydrochloride 可用于急性髓系白血病(AML)和骨髓纤维化(MF)的研究。

生物活性

Pacritinib hydrochloride is a potent inhibitor of both wild-typeJAK2(IC₅₀=23 nM) andJAK2^V617Fmutant (IC₅₀=19 nM). Pacritinib hydrochloride also inhibitsFLT3(IC₅₀=22 nM) and its mutantFLT3^D835Y(IC₅₀=6 nM). Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)^[1]^[2]^[3].

IC₅₀& Target

JAK2^V617F

19 nM (IC₅₀)

JAK3

520 nM (IC₅₀)

JAK1

1280 nM (IC₅₀)

JAK2^wt

23 nM (IC₅₀)

Tyk2

50 nM (IC₅₀)

Clinical Trial

Formula

C₂₈H₃₂N₄O₃.xClH

CAS 号

1228923-43-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.