JAK3-IN-12

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JAK3-IN-12

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1430095-86-5

JAK3-IN-12 (compound 5k) 是一种高效的JAK3抑制剂，对 JAK3、JAK1 和 JAK2 的IC₅₀为 9.5 nM。JAK3-IN-12 可用于类风湿关节炎的研究。

生物活性

JAK3-IN-12 (compound 5k) is a highly potentJAK3inhibitor withIC₅₀values of 9.5 nM, 18 nM and 42 nM forJAK3,JAK1andJAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis^[1].

IC₅₀& Target^[1]

JAK3

9.5 nM (IC₅₀)

JAK1

18 nM (IC₅₀)

JAK2

42 nM (IC₅₀)

体内研究
(In Vivo)

JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability^[1].
Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice^[1].

	T_max(h)	C_max(ng/ml)	t_max(h)	CL (mL/min/kg), iv	AUC_0-α(μg/mL·h)	F (%)
IV (1 mg/kg); PO (3 mg/kg)	0.5	146±48	1.85±0.43	40.37 ± 3.61	192 ± 56	15

Animal Model:	Male C57BL/6J mice^[1]
Dosage:	1 mg/kg for IV; 3 mg/kg for PO
Administration:	IV or PO; single dosage
Result:	Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).

分子量

413.45

Formula

C₁₉H₁₉N₅O₄S

CAS 号

1430095-86-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.