Thi-DPPY

立即咨询

Thi-DPPY

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2307699-34-7

Thi-DPPY (compound 8e) 是一种有效且具有口服活性的JAK3抑制剂，对 BTK、JAK 的IC₅₀值分别为62.4, 1.38 nM。Thi-DPPY 对 HBE 细胞具有抗增殖活性。Thi-DPPY 在体内显示出抗炎活性。Thi-DPPY 具有研究特发性肺纤维化（IPF）的潜力。

生物活性

Thi-DPPY (compound 8e) is a potent and orally activeJAK3inhibitor withIC₅₀values of 62.4, 1.38 nM forBTK,JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)^[1].

IC₅₀& Target^[1]

JAK3

1.38 nM (IC₅₀)

BTK

62.4 nM (IC₅₀)

体外研究
(In Vitro)

DPPY (compound 8e) shows anti-proliferative activity against HBE (human bronchial epithelia) cells with an IC₅₀of 39.0 μM^[1].

体内研究
(In Vivo)

DPPY (30, 60 mg/kg; i.g., once daily for 14 days) shows anti-IPF agents on the lung morphology and lung coefficient in mouse model^[1].
DPPY (30, 60 mg/kg) significantly decreases the expression of IL-6, IL-17A, TNF-α and MDA in lung tissue in a dose dependent manner^[1].

Animal Model:	5-6 week old, 20-25 g, C57BL mice (BLM-induced pulmonary inflammation and pulmonary fibrosis model)^[1]
Dosage:	30, 60 mg/kg
Administration:	I.g.; once daily for 14 days
Result:	Attenuated the pulmonary morphology changes and reduced the collagen disposition induced by BLM in mouse lung.

分子量

566.07

Formula

C₂₈H₂₈ClN₅O₄S

CAS 号

2307699-34-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.