SD-1008 是一种有效的JAK抑制剂。SD-1008 抑制 STAT3、JAK2 和 Src 的酪氨酸磷酸化。SD-1008 还可以降低 STAT3 依赖的荧光素酶活性。SD-1008 通过阻断 JAK-STAT3 信号通路来增强紫杉醇诱导的卵巢癌细胞凋亡 (apoptosis)。
| 生物活性 | SD-1008 is a potentJAKinhibitor. SD-1008 inhibits tyrosyl phosphorylation ofSTAT3,JAK2andSrc. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhancesapoptosisinduced by Paclitaxel in ovariancancercells via directly blocking the JAK-STAT3 signaling pathway[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
