Cobomarsen

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Cobomarsen

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1848257-52-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

MRG-106

Cobomarsen (MRG-106) 是miR-155的寡核苷酸抑制剂。 Cobomarsen 抑制与细胞存活相关的多种基因通路 (JAK/STAT，MAPK/ERK和PI3K/AKT)。Cobomarsen 可用于 B 细胞淋巴瘤的研究。

生物活性

Cobomarsen (MRG-106) is an oligonucleotide inhibitor ofmiR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (includingJAK/STAT,MAPK/ERKandPI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma^[1]^[2].

体外研究
(In Vitro)

Cobomarsen (10 μM; 48-96 h) reduces cell proliferation and induces apoptosis in U2932, OCI-LY3, and RCK8 cells^[2].
Cobomarsen (10 μM; 72 h) significantly increases the expression of the four direct targets in the cell lines that overexpress miR-155^[1].
Cobomarsen (10 μM; 12 days) reduces cellular proliferation and induces apoptosis in MF and HTLV-1+ CTCL cells^[1].
Cobomarsen (10-50 μM; 7 days) reduces phosphorylation of the downstream signalling proteins AKT, ERK1/2, and STAT-3 in primary human activated T cells or MF cell lines^[1].

Cell Proliferation Assay^[2]

Cell Line:	U2932, OCI-LY3 and RCK8 cells
Concentration:	10 μM
Incubation Time:	48, 72, 96 hours
Result:	Concentration-dependently inhibited cell phosphorylation.

Apoptosis Analysis^[2]

Cell Line:	U2932, OCI-LY3 and RCK8 cells
Concentration:	10 μM
Incubation Time:	96 hours
Result:	Triggered a significant induction of late apoptosis in all cell lines.

体内研究
(In Vivo)

Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts^[2].

Animal Model:	Five-to-six weeks old female NSG mice injected with U2932 cells
Dosage:	1 mg/kg
Administration:	I.v. on days 0, 2, 4, and 7
Result:	Reduced tumor growth most significantly at day 7 and day 10.

Clinical Trial

分子量

4736.00

CAS 号

1848257-52-2

Sequence

RNA, (P-thio)((2'-O,4'-C-methylene)m5C-dA-(2'-O,4'-C-methylene)m5C-dG-dA- (2'-O,4'-C-methylene)m5U-(2'-O,4'-C-methylene)m5U-dA-(2'-O,4'-Cmethylene)G-dC-(2'-O,4'-C-methylene)A-(2'-O,4'-C-methylene)m5U-(2'-O,4'-Cmethylene)m5U-(2'-O,4'-C-methylene)A)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.