PARP7-IN-12

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PARP7-IN-12

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2819700-92-8

PARP7-IN-12 是一种有效的PARP7抑制剂，其IC₅₀值为 7.836 nM。PARP7-IN-12 可用于癌症的研究。

生物活性

PARP7-IN-12 is a potentPARP7Inhibitor with anIC₅₀value of 7.836 nM. PARP7-IN-12 can be used in research ofcancer^[1].

IC₅₀& Target^[1]

PARP7

7.836 nM (IC₅₀)

体外研究
(In Vitro)

PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC₅₀values of 20.722 nM in H1373 cells^[1].

体内研究
(In Vivo)

PARP7-IN-12 (compound 85A; 3 and 100 mg/kg; i.v. and p.o.; Balb/c mice) has good pharmacokinetic property^[1].

Animal Model:

Balb/c mice^[1]

Dosage:

3 and 100 mg/kg

Administration:

Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)

Result:

1.19

分子量

545.94

Formula

C₂₃H₂₇ClF₃N₅O₅

CAS 号

2819700-92-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.