EB-47

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EB-47

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

366454-36-6

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

EB-47 是一种有效的PARP-1/ARTD-1选择性抑制剂，IC₅₀值为 45 nM，对 ARTD5 的IC₅₀值为 410 nM，表现出温和的药效。EB-47 模拟底物 NAD⁺，从烟酰胺延伸至腺苷亚区结合。

生物活性

EB-47, a potent and selectivePARP-1/ARTD-1inhibitor with anIC₅₀value of 45 nM, shows modest potency against ARTD5 with anIC₅₀value of 410 nM. EB-47 mimics the substrate NAD⁺ and extends from the nicotinamide to the adenosine subsite^[1].

IC₅₀& Target^[1]

ARTD1/PARP1

45 nM (IC₅₀)

体外研究
(In Vitro)

EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC₅₀values of 0.86 and 1.0 μM, respectively^[1].

体内研究
(In Vivo)

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation^[3].

分子量

537.53

Formula

C₂₄H₂₇N₉O₆

CAS 号

366454-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.