OM-1700 是一种有效的tankyrase抑制剂，对 tankyrase 1 和 tankyrase 2 的IC50分别为 127 和 14 nM。OM-1700 减少结肠癌细胞系 COLO 320DM (GI50= 650 nM) 细胞生长。
| 生物活性 | OM-1700 is a potenttankyraseinhibitor withIC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the coloncancercell line COLO 320DM (GI50=650 nM)[1]. |
| IC50& Target[1] | TNKS1 127 nM (IC50) | TNKS2 14 nM (IC50) |
|
体外研究
(In Vitro) | OM-153 shows inhibition (IC50=19 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay[1].
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
