SK-575-NEG

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SK-575-NEG

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

SK-575-NEG (化合物 28)是 SK-575 的甲基化对应物，由 SK-575 中哌啶-2,6-二酮的氨基甲基化合成，作为对照化合物。SK-575-NEG 与PARP1强结合，其IC₅₀值为 2.64 nM。当浓度达到 1 μM 时，SK-575-NEG 对 MDA-MB-436 和 Capan-1 细胞的 PARP1 降解完全无效。

生物活性

SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound toPARP1, with anIC₅₀of 2.64 nM. SK-575-NEG was completely ineffective in inducingPARP1degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM^[1].

IC₅₀& Target

PARP-1

2.64 nM (IC₅₀)

分子量

891.00

Formula

C₄₈H₅₅FN₈O₈

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.