PARP1-IN-10 是一种无毒、有效的PARP1抑制剂，IC50为 50.62 nM。PARP1-IN-10 导致细胞周期在 G2/M 期停滞和凋亡 (apoptosis)，并能够增强替莫唑胺 (TMZ) 的细胞毒性。
| 生物活性 | PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potentPARP1inhibitor with anIC50value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase andapoptosis, and enhances the cytotoxicity of temozolomide (TMZ)[1]. |
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体外研究
(In Vitro) | PARP1-IN-10 (compound 12c) (10 μM, 48 h) shows no cytotoxic effects against NCI-60 human tumor cell lines[1].
PARP1-IN-10 inhibits MDA-MB-436 cell line with anIC50value of 3.73 μM[1].
PARP1-IN-10 (1 and 3.73 μM, 48 h) causes cell cyle arrest at G2/M with dose-dependent manner[1].
PARP1-IN-10 (0.5 μM, 48 h) shows antiprolifetative effect of temozolomide (TMZ) about 7 times (IC50= 3.64 μM) in A549 cell line compared to TMZ alone (IC50=24.2 μM)[1].
Cell Cytotoxicity Assay[1] | Cell Line: | NCI-60 human tumor cells | | Concentration: | 10 μM | | Incubation Time: | 48 hours | | Result: | Showed no toxicity. |
Cell Cycle Analysis[1] | Cell Line: | MDA-MB-436 cells | | Concentration: | 0, 1, 3.73 μM | | Incubation Time: | 48 hours | | Result: | Caused cell cycle arrest at G2/M and showed apoptotic effect in dose-dependent manner. |
Apoptosis Analysis[1] | Cell Line: | A549 human lung cancer cells | | Concentration: | 0, 0.5, 7.94 μM | | Incubation Time: | 48 hours | | Result: | Potentiated the antiproliferative effect of temozolomide (TMZ) 7 times compared with TMZ alone. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
