CEP-9722

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CEP-9722

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

916574-83-9

CEP-9722 是 CEP-8983 的前药，是一种选择性且具有口服活性的PARP-1和PARP-2抑制剂，IC₅₀分别为 20 nM 和 6 nM。CEP-9722 具有抗癌作用。

生物活性

CEP-9722, the prodrug of CEP-8983, is a selective and orally activePARP-1andPARP-2inhibitor withIC₅₀s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects^[1]^[2].

IC₅₀& Target^[2]

PARP-1

20 nM (IC₅₀)

PARP-2

6 nM (IC₅₀)

体内研究
(In Vivo)

CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; for 5 days a week for 4 weeks) shows dose-dependent antitumor activity in RT4 xenografts; 200 mg/kg daily is better than control and 100 mg/kg is not^[1].

Animal Model:	Nude mice bearing subcutaneous RT4 human urothelial carcinoma (UC) tumors^[1]
Dosage:	100 or 200 mg/kg/day
Administration:	Oral gavage; once daily; for 5 days a week for 4 weeks
Result:	Showed dose-dependent antitumor activity in RT4 xenografts.

Clinical Trial

分子量

418.49

Formula

C₂₄H₂₆N₄O₃

CAS 号

916574-83-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.