PARP1/2/TNKS1/2-IN-1 (Compound I-9) 是一种PARP-1、PARP-2、TNKS1、TNKS2多重抑制剂，对 PARP-1、PARP-2、TNKS1 和 TNKS2 的IC50值分别为 0.25 nM、1.2 nM、13.5 nM 和 4.15 nM。PARP1/2/TNKS1/2-IN-1 表现出良好的协同抗肿瘤作用，诱导细胞凋亡 (apoptosis)。
| 生物活性 | PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dualPARP-1,PARP-2,TNKS1andTNKS2inhibitor withIC50values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and inducesapoptosis[1]. |
| IC50& Target | PARP-1 0.25 nM (IC50) | PARP-2 1.2 nM (IC50) | TNKS2 4.15 nM (IC50) | TNKS1 13.5 nM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
