HBDDE

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HBDDE

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

154675-18-0

HBDDE，Ellagic acid 的衍生物，是一种同种型选择性PKCα和PKCγ抑制剂，IC₅₀值分别为 43 μM 和 50 μM。HBDDE 对PKCα/PKCγ的选择性高于同工酶 PKCδ，PKCβI 和 PKCβII 。HBDDE 可诱导神经元凋亡 (apoptosis)。

生物活性

HBDDE, a derivative of Ellagic acid, is an isoform-selectivePKCαandPKCγinhibitor withIC₅₀s of 43 μM and 50 μM, respectively. HBDDE shows selective forPKCα/PKCγoverPKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronalapoptosis^[1]^[2].

IC₅₀& Target^[1]

PKCα

43 μM (IC₅₀)

PKCγ

50 μM (IC₅₀)

体外研究
(In Vitro)

HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity^[1].

Cell Viability Assay^[1]

Cell Line:	Cerebellar granule cells
Concentration:	50 μM
Incubation Time:	5 hours
Result:	Reduced cell viability significantly by ~70%.

分子量

338.31

Formula

C₁₆H₁₈O₈

CAS 号

154675-18-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.