TAS-301

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TAS-301

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

193620-69-8

TAS-301 是一种平滑肌迁移和增殖抑制剂，能够抑制 PDGF 诱导的PKC的活化。

生物活性

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibitsPKCactivation induced byPDGF.

IC₅₀& Target^[1]

PKC

体外研究
(In Vitro)

TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca²⁺influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively^[1]. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM^[2].

体内研究
(In Vivo)

TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury^[2].

分子量

357.40

性状

Solid

Formula

C₂₃H₁₉NO₃

CAS 号

193620-69-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 38 mg/mL(106.32 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7980 mL	13.9899 mL	27.9799 mL
5 mM	0.5596 mL	2.7980 mL	5.5960 mL
10 mM	0.2798 mL	1.3990 mL	2.7980 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。