SIRT2-IN-9

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SIRT2-IN-9

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

522650-91-5

SIRT2-IN-9 (compound 12) 是SRIT2的选择性抑制剂，IC₅₀值为 1.3 μM。SIRT2-IN-9 抑制 MCF-7 乳腺癌细胞的增殖活性。SIRT2-IN-9 可用于癌症的研究。

生物活性

SIRT2-IN-9 (compound 12) is a selective inhibitor ofSRIT2with anIC₅₀value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breastcancercells. SIRT2-IN-9 can be used for the research ofcancer^[1].

IC₅₀& Target

SIRT2

1.3 μM (IC₅₀)

SIRT1

＞300 μM (IC₅₀)

SIRT3

＞300 μM (IC₅₀)

体外研究
(In Vitro)

SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC₅₀value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC₅₀s ＞300 μM^[1].
SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells^[1].
SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein^[1].

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 breast cancer cell line
Concentration:	0-50 μM
Incubation Time:	72 hours
Result:	Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.

Western Blot Analysis^[1]

Cell Line:	MCF-7 breast cancer cell line
Concentration:	6.25, 12.5, 25 and 50 μM
Incubation Time:	6 hours
Result:	Dose-dependently increased acetylation of α-tubulin protein.

分子量

438.57

性状

Solid

Formula

C₂₁H₂₂N₆OS₂

CAS 号

522650-91-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 4.46 mg/mL(10.17 mM;ultrasonic and warming and heat to 70℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2801 mL	11.4007 mL	22.8014 mL
5 mM	0.4560 mL	2.2801 mL	4.5603 mL
10 mM	0.2280 mL	1.1401 mL	2.2801 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。