Sirt1/2-IN-1

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Sirt1/2-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2402779-21-7

Sirt1/2-IN-1 (Compound 7) 是一种SIRT1和SIRT2抑制剂，对 SIRT1、SIRT2 和SIRT3的IC₅₀值分别为 1.81、2.10 和 20.5 μg/mL。Sirt1/2-IN-1 表现出 α-微管蛋白的超乙酰化活性，IC₅₀值为 32.05 μg/mL。Sirt1/2-IN-1 具有明显抗癌活性。

生物活性

Sirt1/2-IN-1 (Compound 7) is aSIRT1andSIRT2inhibitor withIC₅₀values of 1.81, 2.10 and 20.5 μg/mL againstSIRT1,SIRT2andSIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with anIC₅₀of 32.05 μg/mL. Sirt1/2-IN-1 shows prominent anticancer activity^[1].

IC₅₀& Target

SIRT1

1.81 μg/mL (IC₅₀)

SIRT2

2.10 μg/mL (IC₅₀)

SIRT3

20.5 μg/mL (IC₅₀)

分子量

420.93

Formula

C₂₂H₁₃ClN₂OS₂

CAS 号

2402779-21-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.