SIRT1-IN-3

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SIRT1-IN-3

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CAS NO:

2470969-91-4

SIRT1-IN-3 (compound 3j) 是一种有效且选择性的SIRT1抑制剂，其IC₅₀为 4.2 μM。

生物活性

SIRT1-IN-3 (compound 3j) is a potent and selectiveSIRT1inhibitor, with anIC₅₀of 4.2 μM^[1].

IC₅₀& Target

SIRT1

4.2 μM (IC₅₀)

SIRT2

38 μM (IC₅₀)

体外研究
(In Vitro)

SIRT1-IN-3 (compound 3j) (0-100 μM, 48 h) inhibits the proliferation of human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, and shows low cytotoxic on 293T and HUVEC^[1].

Cell Cytotoxicity Assay

Cell Line:	Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC)^[1]
Concentration:	0, 0.01, 0.1, 1, 10, 100 μM
Incubation Time:	48 h
Result:	Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, with IC₅₀values of 47, 41, 66, 93, 52, and 64 μM, respectively. And showed low cytotoxic on 293T and HUVEC, with an IC₅₀values of 49 and 45 μM, respectively.

分子量

295.18

Formula

C₁₃H₁₅BrN₂O

CAS 号

2470969-91-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.