SIRT1-IN-2

立即咨询

SIRT1-IN-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2470969-89-0

SIRT1-IN-2 (compound 3h) 是一种有效且选择性的SIRT1（沉默信息调节因子1）抑制剂，其IC₅₀为 1.6 μM。

生物活性

SIRT1-IN-2 (compound 3h) is a potent and selectiveSIRT1(silent information regulator 1) inhibitor, with anIC₅₀of 1.6 μM^[1].

IC₅₀& Target

SIRT1

1.6 μM (IC₅₀)

SIRT2

39 μM (IC₅₀)

体外研究
(In Vitro)

SIRT1-IN-2 (compound 3h) (0-100 μM, 48 h) inhibits the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, and shows significantly less cytotoxic on 293T cells and HUVEC^[1].

Cell Cytotoxicity Assay

Cell Line:	Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC).^[1]
Concentration:	0, 0.01，0.1，1，10，100 μM
Incubation Time:	48 h
Result:	Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, with IC₅₀values of 51, 37, 40, 48, and 48 μM, respectively. And showed significantly less cytotoxic on 293T cells and HUVEC, with IC₅₀values of >100 and 45 μM, respectively.

分子量

250.72

Formula

C₁₃H₁₅ClN₂O

CAS 号

2470969-89-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.