5-HT3 antagonist 5

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5-HT3 antagonist 5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

901599-43-7

5-HT3 antagonist 5 是一种喹喔啉 -2- 甲酰胺化合物，是5-HT₃受体拮抗剂。5-HT3 antagonist 5 对5-HT₃激动剂和2-甲基-5-HT也具有拮抗作用，并在小鼠中表现出抗抑郁效果。

生物活性

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a5-HT₃receptorantagonist. 5-HT3 antagonist 5 exerts antagonism on5-HT₃agonist and2-methyl-5-HT, and shows anti-depressant effect in mice^[1].

IC₅₀& Target

5-HT₃Receptor

体外研究
(In Vitro)

5-HT3 antagonist 5 (compound 4c) exhibits 5-HT₃receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT₃agonist, 2-methyl-5-HT, with pA₂value of 5^[1].

体内研究
(In Vivo)

5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice^[1].

Animal Model:	Swiss albino mice (23 ± 2 g)^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration
Result:	Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.

分子量

279.29

性状

Solid

Formula

C₁₆H₁₃N₃O₂

CAS 号

901599-43-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 20.83 mg/mL(74.58 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.5805 mL	17.9025 mL	35.8051 mL
5 mM	0.7161 mL	3.5805 mL	7.1610 mL
10 mM	0.3581 mL	1.7903 mL	3.5805 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。