SB 258741 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

SB 258741 hydrochloride 是一种特异性的5-HT₇受体拮抗剂，可用于精神分裂症的研究。

生物活性

SB 258741 hydrochloride is a specific5-HT₇receptorantagonist and can be used for the research of schizophrenia^[1].

IC₅₀& Target

5-HT₇Receptor

体外研究
(In Vitro)

SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pK_B) is 8.47^[2].

体内研究
(In Vivo)

SB 258741 (0-9.1 mg/kg; s.c.; once or daily for 3 days) shows antipsychotic effects in rats^[1].

Animal Model:	Male Wistar rats, 250 –300 g in the phencyclidine (PCP)-disrupted prepulse inhibition (PPI) and PCP-disrupted social interaction (SIT) paradigm, 200 – 250 g in the catalepsy, motility, and D-amphetamine hyperactivity paradigms^[1]
Dosage:	0.56, 2.3, 4.6 and 9.1 mg/kg
Administration:	Subcutaneous injection, once or daily for 3 days (social interaction test)
Result:	Reversed hyperactivity induced by D-amphet-amine over 0.56 mg/kg, and reduced motility at 4.6 and 9.1 mg/kg. Did not reverse D-Amphetamine-disrupted PPI, but enhanced PCP-disrupted PPI. Reduced PCP (2 mg/kg)-induced hyperactivity.

分子量

386.98

Formula

C₁₉H₃₁ClN₂O₂S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.